Friday, April 17, 2020

WHO Opposes Blood Plasma Treatment For Covid-19,But It Has Cured 5

WHO Opposes Blood Plasma Treatment For Covid-19,But It Has Cured 5.


Cui Bono?The Vaccine producers.

Here are the details regarding the Cure,from the link 2 above.
"Abstract

IMPORTANCE:

Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments.

OBJECTIVE:

To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

DESIGN, SETTING, AND PARTICIPANTS:

Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2 <300; and mechanical ventilation. All 5 were treated with convalescent plasma transfusion. The study was conducted at the infectious disease department, Shenzhen Third People's Hospital in Shenzhen, China, from January 20, 2020, to March 25, 2020; final date of follow-up was March 25, 2020. Clinical outcomes were compared before and after convalescent plasma transfusion.

EXPOSURES:

Patients received transfusion with convalescent plasma with a SARS-CoV-2-specific antibody (IgG) binding titer greater than 1:1000 (end point dilution titer, by enzyme-linked immunosorbent assay [ELISA]) and a neutralization titer greater than 40 (end point dilution titer) that had been obtained from 5 patients who recovered from COVID-19. Convalescent plasma was administered between 10 and 22 days after admission.

MAIN OUTCOMES AND MEASURES:

Changes of body temperature, Sequential Organ Failure Assessment (SOFA) score (range 0-24, with higher scores indicating more severe illness), Pao2/Fio2, viral load, serum antibody titer, routine blood biochemical index, ARDS, and ventilatory and extracorporeal membrane oxygenation (ECMO) supports before and after convalescent plasma transfusion.

RESULTS:

All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. Following plasma transfusion, body temperature normalized within 3 days in 4 of 5 patients, the SOFA score decreased, and Pao2/Fio2 increased within 12 days (range, 172-276 before and 284-366 after). Viral loads also decreased and became negative within 12 days after the transfusion, and SARS-CoV-2-specific ELISA and neutralizing antibody titers increased following the transfusion (range, 40-60 before and 80-320 on day 7). ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. Of the 5 patients, 3 have been discharged from the hospital (length of stay: 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion.

CONCLUSIONS AND RELEVANCE:

In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials."
PMID:
 
32219428
 
PMCID:
 
PMC7101507
 [Available on 2020-09-27]
 
DOI:
 
10.1001/jama.2020.4783

Friday, April 10, 2020

neo-Corona Virus 2019-2020

1.Bio-Weapons and -Warfare are in themselves big topics covering vast areas.
The EU Comic Book,"INFECTED" predicted what is happening now,in 2012!2.The proposed,anti-dote ,by the vested interests,is a Universal Vaccine,containing nano-Microchip,to ID and track a person.This is why the FIXATION on a Vaccine,instead of a Medicine to cure.In the case of SARS,Blood Plasma from a recovered patient was used and hence NO Vaccine for the same,at least in India.


3.Cui Bono? This will provide answers.




4. Use THIS link for latest numbers.

Bill Gates at it again!

5.The Economist’s “The World in 2019” 






   The Pangolin at the bottom is suspected to transmit the Cornavirus from Bats to Humans.
Pan-demic sounds like Pan-golin! It,PAN-GOLIN, is suspected to be threatened by EXTINCTION,which a Pan-demic also causes,sometimes,to all affected by it,at least the Humans.


The following is from Wikipedia :-

Virology[edit]

COVID-19 infection[edit]

Nucleic acid sequences of viruses taken from pangolins had initially been found to be a 99% match with SARS coronavirus 2 (SARS-CoV-2), the virus which causes COVID-19, and responsible for the 2019–20 coronavirus pandemic.[63][64] The working theory of researchers in Guangzhou, China, was that SARS-CoV-2 had originated in bats and, prior to infecting humans, was circulating among pangolins. The illicit Chinese trade of pangolins for use in traditional Chinese medicine was suggested as a vector for human transmission.[63][65] Researchers recently have implicated the pangolins as intermediate hosts in the ongoing coronavirus pandemic as the discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins are hosts for novel coronaviruses. [66] However, further study was less conclusive on pangolins as the definitive source of (SARS-CoV-2), namely being the bridge that the virus used to jump from bats to humans, after it emerged that the 99% match did not actually refer to the entire genome, but to a specific site known as the receptor-binding domain (RBD).[67] A whole-genome comparison found that the pangolin and human viruses share only 90.3% of their RNA.[67] Ecologists worried that the early speculation about pangolins being the source may have led to mass slaughters, endangering the animals further, which was similar to what happened to civets during the SARS